Research Profiles: 

1.Tooth development; 2. Tooth agenesis

Research Expertise

Area of Research Expertise:

1.The genetic basis and molecular mechanism of tooth agenesis

2.The tooth root development and bioengineering

Research Theme: 

1.The pathogenic mechanism of tooth agenesis

2.Epithelial Wnt10a regulates the tooth root furcation formation via Gsk3β and Hedgehog signaling pathway

3.The mechanism of Kdf1 on determining tooth morphogenesis by regulating the polarization and junction of dental epithelial cells

Academic Publications（Representative work）

1.Sun K^#, Yu M^#, Wang J, Zhao H, Liu H, Feng H, Liu Y, Han D*. A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning. Int J Oral Sci. 2024 Mar 13;16(1):25. (IF: 14.9, Q1)

2.Yu P^#, Yang W^#, Han D^#, et al., Mutations in WNT10B Are Identified in Individuals with Oligodontia. Am J Hum Genet. 2016 Jul 7;99(1):195-201. (IF: 10.794, Q1) 

3.Yu M^#, Fan Z^#, Wong SW, Sun K, Zhang L, Liu H, Feng H, Liu Y, Han D*. Lrp6 dynamic expression in tooth development and mutations in oligodontia. J Dent Res. 2021 Apr;100(4):415-422. (IF: 6.116, Q1)

4.Yu M^#, Liu Y^#, Wang Y, Wong SW, Wu J, Liu H, Feng H, Han D*. Epithelial Wnt10a Is Essential for Tooth Root Furcation Morphogenesis. J Dent Res. 2020 Mar;99(3):311-319. (IF: 5.125, Q1)

5.Zhang L^#, Yu M^#, Sun K, Fan Z, Liu H, Feng H, Liu Y, Han D*. Rare phenotype: Hand preaxial polydactyly associated with LRP6-related tooth agenesis in humans. NPJ Genom Med. 2021 Nov 10;6(1):93. (IF：8.617, Q1)

Honours and Awards

IADR/Unilever Hatton Divisional Award, the 1st Prize, International Association of Dental Research, 2013

Chinese Stomatological Association Science and Technology Award, the 2nd Prize, Chinese Stomatological Association, 2018

Beijing Science and Technology Award, the 3rd Prize, People's Government of Beijing Municipality, 2018