Investigators

Research Profiles: 

1)Etiology and Pathogenic mechanism of Periodontal Diseases and Periimplantitis.

2)Homeostasis of Periodontal Ligament and Periodontal Regeneration.

3)Virtual Reality in Stomatology.

4)Application of Digital Technology in Periodontics.

5)Multidisciplinary Treatment of Patients with Severe Periodontitis.

Academic Publications

1)Jian Liu^#, Xiao Xu^#, Hui-Fang Yang, Ye Han, Meng-Qiao Pan, Jia-Ming Li, Li Xu*, Jian-Xia Hou*. A nomogram prediction of gingival recession in mandibular incisors of orthodontic-orthognathic treated skeletal class III malocclusion with or without PAOO: A retrospective cohort study. Heliyon. 2024; 10: e33478.

2)Jian Liu^#, Yi Li^#, Hui-Fang Yang, Ye Han, Meng-Qiao Pan, Jia-Ming Li, Li Xu*, Jian-Xia Hou*. Simultaneous Labial and Lingual Augmented Corticotomy Asisted Presurgical Orthodontics in Class Ⅲ Patients: The Morphological Aspects of the Mandibular Anterior Ridge with Cone-beam computed tomography. Clinical Oral Investigations. 2024; 

3)Churen Zhang,  Ye Han, Lili Miao, Zhaoguo Yue, Min Xv, Kaining Liu* and Jianxia Hou*. Human-β-defensins are correlated with the immune infiltration and regulated by vitamin D3 in periodontitis. Journal of Periodontal Research. 2023; 58(5): 986-996.

4)Xu M^#, Zhang C^#, Han Y, Zhang J, Chang X, Hou J*, Li Sha*. TNF-α promotes expression of inflammatory factors by upregulating nicotinamide adenine dinucleotide phosphate oxidase-2 expression in human gingival fibroblasts. J Dent Sci. 2024; 19(1): 211-219.

5)Ye Han^#, Zhiqiang Luo^#, Zhaoguo Yue, Lili Miao, Min Xv, Shu Chang, Yalin Zhan*, Jianxia Hou*. The tendency of anemia of inflammation in periodontal diseases. Clin Sci (Lond).  2023; 137(3): 251-264. 

6)Ye Han^#, Lili Miao^#, Zhaoguo Yue, Chang Shu, Jian Liu, Mingxin Mao, Li Xu*, Jianxia Hou*. Periodontal soft tissue augmentation induced by periodontally accelerated osteogenic orthodontics surgery. BMC Oral Health. 2022; 22(1): 506. 

7)Hongbo Zhu, Guangjie Han*, Jianxia Hou*, Xiangliang Liu, Yue Ma. Knowledge Sharing for Pulmonary Nodule Detection in Medical Cyber-Physical Systems. IEEE Journal of Biomedical and Health Informatics (IEEE J BIOMED HEALTH ). 2023; 27(2): 625-635. 

8)Zhaoguo Yue, Qi Liu, Haidong Zhang, Jingwen Yang, Lili Miao, and Jianxia Hou*.  Clinical, Histological and Radiological Outcomes of Sinus Floor Elevation Using a New Approach before Extraction of Periodontally Hopeless Maxillary Molars: A Case Report with 3 Years of Follow-up. Case Reports in Dentistry. 2022  Nov 15;2022:8143765. 

9)Churen Zhang, Yuzhe Sun, Zhaoguo Yue, Chang Shu, Jianxia Hou*, Dongchen Ou*. Potential links between COVID-19 and periodontitis: a bioinformatic analysis based on GEO datasets. BMC Oral Health. 2022 Nov 21; 22(1): 520. 

10)Min Xv^#, Churen Zhang^#, Ye Han, Zhaoguo Yue, Chang Shu, Jianxia Hou*. Association between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility: a meta-analysis. BMC Oral Health. 2022 Dec 12;22(1):598. doi: 10.1186/s12903-022-02657-6.

11)Ye Han, Qingsong Yu, Xiaoqing Dong, Jianxia Hou*, Jianmin Han*. Plasma SiOx:H Nanocoatings to Enhance the Antibacterial and Anti-inflammatory Properties of Biomaterials. International Journal of Nanomedicine. 2022; 17: 381-394.

12)Wenfeng Song, Xia Hou, Shuai Li*, Chenglizhao Chen, Danyang Gao, Xian’e Wang, Yuzhe Sun, Jianxia Hou*, Aimin Hao. An Intelligent Virtual Standard Patient for Medical Students Training Based on Oral Knowledge Graph. IEEE Transactions on Multimedia. 2023; 25: 6132-6145. 

13)Shiliang Shao, Guangjie Han*, Ting Wang, Chunhe Song, Chen Yao, and Jianxia Hou*. Obstructive Sleep Apnea Detection Scheme Based on Manually Generated Features and Parallel Heterogeneous Deep Learning Model under IoMT. IEEE Journal of Biomedical and Health Informatics (IEEE J BIOMED HEALTH ). 2022; 26(12): 5841-50. 

14)Churen Zhang, Qi Liu, Jingwen Yang, Jianxia Hou*. A digital technique for splinting periodontally compromised mobile teeth in the mandibular anterior region. The Journal of Prosthetic Dentistry (J Prosthet Dent ). 2021; 125(4): 560-563. May 12; S0022-3913 (20) 30218-3.

15)Jingwen Yang ,Pingyi Jia Zhaoguo Yue ,Jianzhang Liu ,Zhongning Liu ,Lin Tang ,Qi Liu ,Jianxia Hou *. Microbiological and clinical evaluation of ultrasonic debridement with/without erythritol air-polishing during supportive periodontal therapy in arches with full-arch fixed implant-supported prostheses: Protocol for a randomised controlled trial. BMJ Open. 2021 Dec 7;11(12): e053286.

16)Hongbo Zhu, Guangjie Han*, Chuan Lin, Mohsen Guizani, Jianxia Hou*, Wei Xing. Two-Way MR-Forest Based Growing Path Classification for Malignancy Estimation of Pulmonary Nodules. IEEE Journal of Biomedical and Health Informatics (IEEE J BIOMED HEALTH). 2021; 25(10):3752-3762.

17)Chu-Ren Zhang, Kai-Ning Liu*, Jian-Xia Hou*. Extending vitamin D pathway to vitamin D3 and CYP27A1 in periodontal ligament cells. J Periodontol. 2021; 92(7): 44-53.

18)Zhaoguo Yue, Qi Liu, Haidong Zhang, Jingwen Yang, Jianxia Hou*. Histological, radiological, and clinical outcomes of sinus floor elevation using a lateral approach for pre-/post-extraction of the severely compromised maxillary molars: A study protocol for a randomized controlled clinical trial. Trials. 2021; 22(1): 101. 

19)Ye Han, Wenxue Huang, Lili Miao, Yalin Zhan, Jianxia Hou*. Pro-inflammatory cytokine interleukin-6-induced hepcidin, a key mediator of periodontitis related anemia of inflammation. Journal of Periodontal Research. 2021; 56(4): 690-701. 

20)Yang, Jing-Wen; Liu, Qi; Yue, Zhao-Guo; Hou, Jian-Xia*; Afrashtehfar, Kelvin. Digital workflow for full-arch immediate implant placement using a stackable surgical guide fabricated using SLM technology. Journal of Prosthodontics (Journal of Prosthodontics-Implant Esthetic and Reconstructive Dentistry). 2021; 30(8): 645-650.

21)Chu-Ren Zhang, Hai-Dong Zhang, Zhao-Guo Yue, Li-Li Miao, Ye Han, Kai-Ning Liu*, Jian-Xia Hou*. Modified minimally invasive surgical technique plus Bio-Oss  Collagen for regenerative therapy of isolated interdental intrabony defects: study protocol for a randomised controlled trial. BMJ Open. 2020 Dec 10;10(12): e040046.

22)Yan Y, Zhan Y, Wang X, Hou J*. Clinical evaluation of ultrasonic subgingival debridement versus ultrasonic subgingival scaling combined with manual root planing in the treatment of periodontitis: study protocol for a randomized controlled trial. Trials. 2020; 21(1):113-119.

23)Pingyi Jia^#, Jingwen Yang^#, Zhaoguo Yue, Jianzhang Liu, Qi Liu, Zhongning Liu, Lin Tang, Jianxia Hou*. Comparison of peri-implant submucosal microbiota in arches with zirconia or titanium implant-supported fixed complete dental prostheses: a study protocol for a randomized controlled trial. Trials. 2020 Nov 27;21(1): 979.

24)Huang W, Zhan Y , Zheng Y, Han Y, Hu W , Hou J *. Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways.  Clin Sci (Lond).  2019; 133(1): 135-148.

25)Wenxue Huang, Wei Li, Weidong Zhu, Juan Liu, Jianxia Hou*, Huanxin Meng*. Ferritin expression in the periodontal tissues of primates. European Journal of Histochemistry. 2019; 63(3): 3046.

26)Wang D , Li T , Zhang Y , Hou J *. Survey on multisensory feedback virtual reality dental training systems. Eur J Dent Educ.  2016 Nov;20(4):248-260.

27)Li W , Huang B , Liu K , Hou J *, Meng H *. Upregulated Leptin in Periodontitis Promotes Inflammatory Cytokine Expression in Periodontal Ligament Cells. J Periodontol. 2015 Jul;86(7):917-26.

28)Gao H , Zhang X , Zheng Y , Peng L , Hou J *, Meng H *. S100A9-induced release of interleukin (IL)-6 and IL-8 through toll-like receptor 4 (TLR4) in human periodontal ligament cells. Mol Immunol.  2015; 67(2 Pt B): 223-32. 

29)Yunfei Zheng^#, Jianxia Hou^#, Lei Peng, Xin Zhang, Lingfei Jia, Xian’e Wang, Shicheng Wei, Huanxin Meng*. The Pro-apoptotic and Pro-inflammatory Effects of Calprotectin on Human Periodontal Ligament Cells. PLoS One.  2014; 9(10): e110421.

30)JX Hou, S Yamada*, T Kajikawa, N Ozaki, T Awata, S Murakami. Iron plays key role in cytodifferentiation of human periodontal ligament cells. J Periodontol Res. 2014; 49(2): 260-7.

31)Jianxia Hou, Satoru Yamada, Tetsuhiro Kajikawa, Nobuhiro Ozaki, Toshihito Awata, Satoko Yamaba, Shinya Murakami*. Role of ferritin in the cytodifferentiation of periodontal ligament cells. Biochem Biophys Res Commun.  2012; 426(4):643-8.

32)殳畅^#，韩烨^#，孙雨哲，杨再目，侯建霞*.  Ⅲ期牙周炎患者牙周基础治疗前后炎症性贫血相关指标的变化. 北京大学学报（医学版）, 2024; 56(1):45-50.

33)孙雨哲^#，王宪娥^#，侯建霞*.虚拟标准化病人在医学教育中的应用与研究进展.中华医学教育杂志，2024; 44(4): 294-298.

34)孙雨哲^#，王宪娥^#，张芮初，潘朗新，侯建霞*.三维虚拟仿真牙周病患者病例库的构建及其在前期教学中的应用.中华医学教育杂志，2024; 44(5): 349-352.

35)岳兆国，刘琦，杨静文，侯建霞*. 牙膏残留物相关的种植体周炎1例. 中华口腔医学杂志. 2023; 58 (3)：277-280. DOI: 10.3760/cma.j.cn112144-20220824-00458. 

36)孙佳^#，韩烨^#，侯建霞*. 白细胞介素-6-铁调素信号轴调控牙周炎相关性贫血致病机制的研究进展. 国际口腔医学杂志. 2023; 50(1):69-75. 

37)郭姣姣，侯建霞*，陈庆勇.牙周病与缺血性脑卒中的关系.现代口腔医学杂志. 2021; 35(1): 50-53.

38)岳兆国，张海东，杨静文，侯建霞*.数字化评估CAD/CAM个性化基台与成品基台影响粘接剂残留的体外研究. 北京大学学报（医学版）, 2021; 53(1):69-75.

39)闫乐，侯建霞*.龈下清创术与根面平整术. 国际口腔医学杂志, 2021; 48(1):29-34.

40)郜洪宇，黄宝鑫，侯建霞*，孟焕新*. S100A8、S100A9蛋白在健康和实验性牙周炎组织中的表达. 中华口腔医学杂志. 2020; 55 (6): 402-407.

41)闫乐，王宪娥，詹雅琳，苗莉莉，韩烨，张楚人，岳兆国，胡文杰，侯建霞*. 超声龈下清创联合手工根面平整术治疗重度牙周炎的临床效果. 北京大学学报（医学版）, 2020; 52(1): 64-70.

42)韩烨, 苗莉莉, 靖无迪, 李晓彤，赵一姣，徐莉，侯建霞*. 牙周组织再生结合骨皮质切开术对骨性Ⅲ类错牙合牙龈厚度影响的数字化评估[J]. 中华口腔医学杂志. 2020; 55 (2): 73-79.

43)赖思煜，侯建霞*.牙槽嵴保存在牙周炎与非牙周炎患牙拔牙位点的应用进展[J]. 中华口腔医学杂志. 2020; 55 (4): 266-270.

44)吴晓楠, 马宁, 侯建霞*.不同干细胞来源外泌体在牙周再生领域的研究进展. 国际口腔医学杂志. 2020; 47(2):146-151.

45)苗莉莉，韩烨，詹雅琳，侯建霞*. 数字化技术在牙周特色软组织增量术中的应用. 中国实用口腔科杂志，2020; 13(8): 456-460.

46)苏静，杨静，侯建霞*. 动力驱动磨锐与手工磨锐龈下刮治器时器械损耗量的比较. 实用口腔医学杂志. 2020; 36(5): 39-42.

47)吴季霖，侯建霞*. 无托槽隐形矫治对牙周健康及牙周炎患者牙周状态的影响. 中华口腔医学杂志, 2019; 54(1)：62-66.

48)侯建霞，张艳玲，詹雅琳，黄文雪，苗莉莉，王党校. 虚拟现实视听触多感觉反馈牙周模拟操作系统对牙周前期训练的影响.中华医学教育杂志, 2018; 38(1)：86-89.

49)詹雅琳，章嫄，侯建霞*. 不同类型牙龈裂的临床治疗策略. 中华口腔医学杂志, 2018; 53(5)：351-354.

50)侯建霞，石巧. 虚拟现实技术在牙科操作培训中的应用. 国际口腔医学杂志, 2015; 42 (1): 69-74. 

51)郑云飞，彭磊，张欣，侯建霞*，孟焕新*. 人重组S100A8对牙周膜细胞增殖和迁移活性的影响. 北京大学学报(医学版), 2013, 45(2): 81-85.

52)侯建霞, 康军, 周爽英, 欧阳翔英. 口腔牙周病学研究生文献课学习的改良和评价.中华医学教育杂志, 2013;33(4):606-607.

53)侯建霞, Peter M Loomer.低氧对人牙周膜干细胞骨向分化影响的实验研究.中华口腔医学杂志 2009;44(9):543-547

54)侯建霞，邵磊，Peter M Loomer，Barron Hong. 牙龈卟啉单胞菌超声提取物对人牙周膜干细胞表达血管内皮生长因子的影响. 实用口腔医学杂志，2007; 23(2): 176-179.

55)侯建霞，Peter M Loomer, Barron Hong.牙龈卟啉单胞菌超声提取物对人牙周膜干细胞骨向分化的影响.现代口腔医学杂志，2007,21(6):603-605.