Guo Yuxing

General Information

Title:Associate Professor

Discipline area:Oral and maxillofacial surgery


Research Profiles:

1. Oral and maxillofacial oncology

2. Oral and maxillofacial plastic and reconstructive surgery

3. Clinical treatment of medication-related osteonecrosis of the jaw

4. Navigation-guided surgery of infratemporal-fossa skull base tumors.

Research Expertise:

1. Interplay between mesenchymal stem cells and osteoclast.

2. Cancer stem cells and tumor immune micro-environment modulation

3. Disease mechanism and new material treatment of MRONJ

4. Research on the recognition of early cancer lymphatic metastasis with high spectrometry combined with artificial intelligence

Major publications

[1] Qiao Q, Xu L, Li Q, Wang Y, Lu H, Zhao N, Pu Y, Wang L, Guo Y, Guo C. Bone morphogenetic protein receptor 1α promotes osteolytic lesion of oral squamous cell carcinoma by SHH-dependent osteoclastogenesis. Cancer Sci. 2022;113(5):1639-1651.

[2] Pu Y, Li Q, Wang Y, Xu L, Qiao Q, Guo Y, Guo C. pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells. BMC Cancer. 2021;21(1):1283.

[3] Li Q, Xu L, Li Y, Yang R, Qiao Q, Wang Y, Wang L, Guo Y, Guo C. P2RY14 is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients with Head and Neck Cancer. Frontiers in Genetics. 2021;12:1190.

[4] Qingxiang Li, Yinfei Pu, Han Lu, Ning Zhao, Yifei, Wang, Yuxing Guo and Chuanbin Guo. Porphyromonas Treponema and Mogibacterium promote IL8 IFN TNF based pro inflammation in patients with medication related osteonecrosis of the jaw. Journal of Oral Microbiology, 2021, 13:1, 1851112.

[5] Li Q, Wang Y, Xu L, Wang L, Guo Y, Guo C. High level of CD10 expression is associated with poor overall survival in patients with head and neck cancer. Int J Oral Maxillofac Surg. 2021 Jul;50(7):857-864.

[6] Y. Wang, Q. Li, L. Xu, J. Chen, Y. Pu, L. Wang, H. Sun, Y. Guo and C. Guo, Cancer stemness of CD10-positive cells regulated by Hedgehog pathway promotes the resistance to cisplatin in oral squamous cell carcinoma. Oral Dis. 2021;27(6):1403-1411.

[7] Li Q-X, Yang R, Wang Y-F, Sun H-F, Wang H-B, Liu H, Guo Y-X, Guo CB, MR imaging as a precise technique to evaluate skull-base tumor volume: comparison of CT, MR imaging and FDG PET from murine and clinical data, Journal of Cranio-Maxillofacial Surgery, 2020 Jan;48(1):105-110.

[8] Yuxing Guo, Yuan Yuan, Ling Wu, et al. BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair. Bone Research (2018) 6:30 ;

last text: Su Jiazeng