Investigators

Research Profiles:

1. Oral and maxillofacial oncology

2. Oral and maxillofacial plastic and reconstructive surgery

3. Clinical treatment of medication-related osteonecrosis of the jaw

4. Navigation-guided surgery of infratemporal-fossa skull base tumors

Research Expertise：

1. Interplay between mesenchymal stem cells and osteoclast.

2. Cancer stem cells and tumor immune micro-environment modulation

3. Disease mechanism and new material treatment of MRONJ

4. Research on the recognition of early cancer lymphatic metastasis with high spectrometry combined with artificial intelligence

Major publications

[1]Huang H, Qiao Q, Zhao N, Zhou Y, Zou Y, Li Q, Li S, Zhou B, Zhang Y, Guo C, Guo Y. Efficacy of submental island flap closing advanced mandibular MRONJ lesion in malignancy patients. Head Neck. 2024;46(9):2315-2326.

[2]Zhang X, Li Q, Li W, Guo Y, Zhang J, Guo C, Chang K, Lovell NH. FD-Net: Feature Distillation Network for Oral Squamous Cell Carcinoma Lymph Node Segmentation in Hyperspectral Imagery. IEEE J Biomed Health Inform. 2024;28(3):1552-1563

[3]Li Q, Li Y, Qiao Q, Zhao N, Yang Y, Wang L, Wang Y, Guo C*, Guo Y*. Oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interleukin-10. Int J Oral Sci. 2023 11;15(1):56.

[4]Yang Y, Li Q, Qiao Q, Zhao N, Huang H, Zhou Y, Guo C, Guo Y. Bacterial distribution and inflammatory cytokines associated with oral cancer with and without jawbone invasion-a pilot study. Clin Oral Investig. 2023;27(12):7285-7293. 

[5]Zhao N, Li QX, Wang YF, Qiao Q, Huang HY, Guo CB, Guo YX. Anti-angiogenic drug aggravates the degree of anti-resorptive drug-based medication-related osteonecrosis of the jaw by impairing the proliferation and migration function of gingival fibroblasts. BMC Oral Health. 2023 May 27;23(1):330.

[6] Qiao Q, Xu L, Li Q, Wang Y, Lu H, Zhao N, Pu Y, Wang L, Guo Y, Guo C. Bone morphogenetic protein receptor 1α promotes osteolytic lesion of oral squamous cell carcinoma by SHH-dependent osteoclastogenesis. Cancer Sci. 2022;113(5):1639-1651.

[7] Pu Y, Li Q, Wang Y, Xu L, Qiao Q, Guo Y, Guo C. pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells. BMC Cancer. 2021;21(1):1283.

[8] Li Q, Xu L, Li Y, Yang R, Qiao Q, Wang Y, Wang L, Guo Y, Guo C. P2RY14 is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients with Head and Neck Cancer. Frontiers in Genetics. 2021;12:1190.

[9] Qingxiang Li, Yinfei Pu, Han Lu, Ning Zhao, Yifei, Wang, Yuxing Guo and Chuanbin Guo. Porphyromonas Treponema and Mogibacterium promote IL8 IFN TNF based pro inflammation in patients with medication related osteonecrosis of the jaw. Journal of Oral Microbiology, 2021, 13:1, 1851112.

[10] Li Q, Wang Y, Xu L, Wang L, Guo Y, Guo C. High level of CD10 expression is associated with poor overall survival in patients with head and neck cancer. Int J Oral Maxillofac Surg. 2021;50(7):857-864.

[11] Y. Wang, Q. Li, L. Xu, J. Chen, Y. Pu, L. Wang, H. Sun, Y. Guo and C. Guo, Cancer stemness of CD10-positive cells regulated by Hedgehog pathway promotes the resistance to cisplatin in oral squamous cell carcinoma. Oral Dis. 2021;27(6):1403-1411.

[12] Li Q-X, Yang R, Wang Y-F, Sun H-F, Wang H-B, Liu H, Guo Y-X, Guo CB, MR imaging as a precise technique to evaluate skull-base tumor volume: comparison of CT, MR imaging and FDG PET from murine and clinical data, Journal of Cranio-Maxillofacial Surgery, 2020;48(1):105-110.