Investigators

Research Profiles:

1. Tooth development

2. Tooth agenesis

Research Expertise

Area of Research Expertise:

1. The genetic basis and molecular mechanism of tooth agenesis

2. The tooth root development and bioengineering 

Research Theme:

1. The pathogenic mechanism of tooth agenesis

2. Epithelial Wnt10a regulates the tooth root furcation formation via Gsk3β and Hedgehog signaling pathway

Academic Publications（Representative work）

1. Yu P#, Yang W#, Han D#, et al., Mutations in WNT10B Are Identified in Individuals with Oligodontia. Am J Hum Genet. 2016 Jul 7; 99 (1): 195-201. (IF: 10.794, Q1)

2. Yu M, Liu Y, Han D*, et al., Epithelial Wnt10a is essential for tooth root furcation morphogenesis. J Dent Res. 2019. In press. (IF: 5.125, Q1)

3. Shen W, Han D*, Feng H, et al., Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. PLoS One. 2016 May 4; 11 (5): e0154884. (IF: 3.057, Q1)

4. Fan Z#, Han D*, Feng H, et al., Novel PITX2 mutations identified in Axenfeld-Rieger syndrome and the pattern of PITX2-related tooth agenesis. Oral Dis. 2019 Sep 16. doi: 10.1111/odi.13196. (IF: 2.625, Q1)

5. Yu M, Han D*, Cai T*, et al., Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis. Oral Dis. 2019 Apr; 25 (3): 646-651. (IF: 2.625, Q1)