Investigators

Research Profiles: 

1. Mesenchymal Stem Cell Mediated Bone Regeneration

2. Apoptotic Body Promote Stem Cell Function to Improve Bone Regeneration

3. Biology and Biomechanics Translational Research of Orthodontic Tooth Movement 

Academic Publications

1. Liu D*#, Yan B, Lei F, Li J, Wang X, Rong Q, Zhou Y. Different sliding mechanics in space closure of lingual orthodontics: a translational study by three-dimensional finite element method. Am J Transl Res. 2019 Jan 15; 11 (1): 120-130.

2. Dawei Liu*#, Jing Li, Feifei Lei, Xuedong Wang, Yanheng Zhou. Dentoskeletal and soft tissue changes associated with miniscrew anchorage in customized lingual orthodontics. Journal of International Medical Research 2019 Jan; 47 (1): 84-95.

3. Li Q, Han G, Liu D, Zhou Y. Force-induced decline of TEA domain family member 1 contributes to osteoclastogenesis via regulation of Osteoprotegerin. Arch Oral Biol. 2019 Apr; 100: 23-32.

4. Liu Dawei*, Kou Xiaoxing, Chen Chider et al. Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors. Cell Research, 2018, 28: 918-933.

5. Yan B, Liu D*#, Zhang C, Zhang T, Wang X, Yang R, Liu Y, He D, Zhou Y. Obesity attenuates force-induced tooth movement in mice with the elevation of leptin level: a preliminary translational study. Am J Transl Res. 2018 Dec 15; 10 (12): 4107-4118.

6. Liu Shiyu, Liu Dawei, Chen Chider, Hamamura Kazunori, Moshaverinia Alireza, Yang Ruili, Liu, Yao Jin, Yan(*), Shi Songtao(*), MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus.,Cell Metab, 2015, 22 (4): 606-618.

7. Liu Y, Jing H, Kou X, Chen C, Liu D, Jin Y, Lu L, Shi S. PD-1 is required to maintain stem cell properties in human dental pulp stem cells. Cell Death Differ. 2018 Jul; 25 (7): 1350-1360.

8. Li Y, Zhong C, Liu D, Yu W, Chen W, Wang Y, Shi S, Yuan Y. Evidence for Kaposi Sarcoma Originating from Mesenchymal Stem Cell through KSHV-induced Mesenchymal-to-Endothelial Transition. Cancer Res. 2018 Jan 1; 78 (1): 230-245.

9. Xiao N, Yu WY, Liu D. Glial cell-derived neurotrophic factor promotes dental pulp stem cell migration. J Tissue Eng Regen Med. 2018 Mar; 12 (3): 705-714.

10. Fu C, Luo D, Yu M, Jiang N, Liu D, He D, Fu Y, Zhang T, Qiao Y, Zhou Y, Liu Y. Embryonic-Like Mineralized Extracellular Matrix/Stem Cell Microspheroids as a Bone Graft Substitute. Adv Healthc Mater. 2018 Aug 7: e1800705.

11. Yang R, Liu Y, Yu T, Liu D, Shi S, Zhou Y, Zhou Y. Hydrogen sulfide maintains dental pulp stem cell function via TRPV1-mediated calcium influx. Cell Death Discov. 2018, 27; 5: 1.

12. Yang R, Yu T, Kou X, Gao X, Chen C, Liu D, Zhou Y, Shi S. Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter. Nat Commun. 2018 Jun 1; 9 (1): 2143.

13. Yang R, Yu T, Liu D, Shi S, Zhou Y. Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway.Stem Cell Res Ther. 2018 Mar 9; 9 (1): 62. doi: 10.1186/s13287-018-0804-6.

14. Zhang C, Yan B, Cui Z, Cui S, Zhang T, Wang X, Liu D, Yang R, Jiang N, Zhou Y, Liu Y. Bone regeneration in minipigs by intrafibrillarly-mineralized collagen loaded with autologous periodontal ligament stem cells. Sci Rep. 2017 Sep 5; 7 (1): 10519. doi: 10.1038/s41598-017-11155-7.

15. Liu F, Wen F, He D, Liu D, Yang R, Wang X, Yan Y, Liu Y, Kou X, Zhou Y. Force-Induced H2S by PDLSCs Modifies Osteoclastic Activity during Tooth Movement. J Dent Res. 2017 Jun; 96 (6): 694-702.

16. Wu B, Kou X, Zhang C, Zhang Y, Cui Z, Wang X, Liu D(*), Zhou Y(*). Stretch force guides finger-like pattern of bone formation in suture. PLoS One 2017; 12 (5): e0177159.

17. Chen C, Wang D, Moshaverinia A, Liu D, Kou X, Yu W, Yang R, Sun L, Shi S. Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis. Cell Res. 2017 Apr; 27 (4): 559-577.

18. Feng L, Zhang Y, Kou X, Yang R, Liu D, Wang X, Song Y, Cao H, He D, Gan Y, Zhou Y. Cadherin-11 modulates cell morphology and collagen synthesis in periodontal ligament cells under mechanical stress. Angle Orthod. 2017 Mar; 87 (2): 193-199.

19. Wang L, Liu S, Zhao Y, Liu D, Liu Y, Chen C, Karray S, Shi S, Jin Y. Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass. Cell Death Differ, 2015, 22 (10): 1654-1664.

20. Liu W, Zhou Y, Wang X, Liu D, Zhou S.Effect of maxillary protraction with alternating rapid palatal expansion and constriction vs expansion alone in maxillary retrusive patients: a single-center, randomized controlled trial. Am J Orthod Dentofacial Orthop. 2015 Oct; 148 (4): 641-51.

21. Yan Y, Liu F, Kou X, Liu D, Yang R, Wang X, Song Y, He D, Gan Y, Zhou Y. T Cells Are Required for Orthodontic Tooth Movement. J Dent Res, 2015, 94 (10): 1463-1470.

22. He D, Kou X, Yang R, Liu D, Wang X, Luo Q, Song Y, Liu F, Yan Y, Gan Y, Zhou Y(*), M1-like Macrophage Polarization Promotes Orthodontic Tooth Movement., J Dent Res, 2015, 94 (9): 1286-1294.

23. Zeng M , Kou X, Yang R, Liu D, Wang X, Song Y, Zhang J, Yan Y, Liu F, He D, Gan Y, Zhou Y(*), Orthodontic Force Induces Systemic Inflammatory Monocyte Responses. J Dent Res, 2015, 94 (9): 1295-1302.

24. Yang Ruili , Qu Cunye，Zhou Yu，Konkel Joanne E, Shi Shihong, Liu Yichen, Chider, Liu Shiyu, Liu Dawei, Chen Yibu, Zandi Ebrahim Chen Wanjun, Zhou Yanheng(*), Shi Songtao(*), Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity, 2015, 43 (2): 251-263.

25. Liu Y, Chen C, Liu S, Liu D, Xu X, Chen X, Shi S , Acetylsalicylic acid treatment improves differentiation and immunomodulation of SHED. J Dent Res, 2015, 94 (1): 209-218.

26. He D, Kou X, Luo Q, Yang R, Liu D, Wang X, Song Y, Cao H, Zeng M, Gan Y, Zhou Y, Enhanced M1/M2 macrophage ratio promotes orthodontic root resorption. J Dent Res, 2015, 94 (1): 129-139.

27. Liu Y, Wang L, Liu S, Liu D, Chen C, Xu X, Chen X, Shi S (*) Transplantation of SHED prevents bone loss in the early phase of ovariectomy-induced osteoporosis. J Dent Res, 2014, 93 (11): 1124-1132.

28. Cao H, Kou X, Yang R, Liu D, Wang X, Song Y, Feng L, He D, Gan Y, Zhou Y(*), Force-induced Adrb2 in periodontal ligament cells promotes tooth movement. J Dent Res, 2014, 93 (11): 1163-1169.