Investigators

Research Profiles:

1. Oral microbiome and salivary peptidome

2. Craniofacial Development and Cleft Lip with/without Cleft Palate

Research Expertise

Area of Research Expertise:

1. Oral microbiome/salivary peptidome on oral diseases

2. Molecular and cellular biology on craniofacial development 

Research Theme:

1. Investigatedsalivary peptidome and microbiome profiles in oral cavity. Demonstrated evident salivary dysbiosis and different ecotypes in IBD communities and provided an option for identifying at-risk populations.

2. Studied the mechanism of craniofacial development and conducted whole-exome sequencing in hereditary families affected with non-syndromic CL/P, and identified novelmutations which is potentiallycausative for the disease. 

Academic Publications

1. Ai TT, Zhang JN, Wang XD, Zheng XW, Qin XY, Zhang Q, Li WR, Hu W, Lin JX*, Chen F*. The DNA methylation profiling is associated with osteogenic potential of three distinct human odontogenic stem cells. Signal Transduction & Targeted Therapy, 2018 Jan 12; 3: 1.

2. Zhao HX, Zhong WJ, Leng C, Zhang JN, Zhang MQ, Huang WB, Zhang YF, Li WR, Jia PZ, Lin JX, Maimaitili G*, Chen F* A novel PTCH1 mutation underlies nonsyndromic cleft lip and/or palate in a Han Chinese family.Oral Dis. 2018 Jun 16. doi: 10.1111/odi.12915.

3. Zhang SJ, Meng PQ, Zhang JN, Jia PZ, Lin JX, Wang XF, Chen F*, Wei XX*. Machine Learning Models for Genetic Risk Assessment of Infants with Non-Syndromic Orofacial CleftGenomics, Proteomics & Bioinformatics, 2018Dec 19. pii: S1672-0229 (18) 30435-2.

4. Gao L, Xu TS, Huang G, Jiang S, Gu Y, Chen F*.Oral microbiomes: more and more importance in oral cavity and whole body.Protein Cell. 2018 May 7. (Review)

5. Xun Z, Zhang Q, Xu T*, Chen N*, Chen F*. Dysbiosis and Ecotypes of the Salivary Microbiome Associated With Inflammatory Bowel Diseases and the Assistance in Diagnosis of Diseases Using Oral Bacterial Profiles.Front Microbiol. 2018 May 30; 9: 1136.

6. Zheng XW#, Chen F#, Zhang Q, Liu Y, You P, Sun S, Lin J*, Chen N*.Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease.Protein Cell. 2017 May 18. doi: 10.1007/s13238-017-0413-7.

7. Hong YY, Zhang JY, Zhang HY, Li X, Qu JF, Zhai JM, Zhang L, Chen F*, Li TJ*. Heterozygous PTCH1 Mutations Impact the Bone Metabolism in Patients With Nevoid Basal Cell Carcinoma Syndrome Likely by Regulating SPARC Expression. J Bone Miner Res. 2016 Jul; 31 (7): 1413-28.IF=6.2839

8. Zheng H, Xu LX, Wang ZC, Li LS, Zhang JN, Zhang Q, Chen T*, Lin JX*, Chen F*. Subgingival microbiome in patients with healthy and ailing dental implants.Scientific Reports, 2015, 5:10948.

9. Zhang JN, Zhou SN, Zhang Q, Feng S, Chen YL, Zheng H, Zhao WH, Zhang TW, Zhou YH, Deng HT, Lin JX*, Chen F*. Proteomic Analysis of RBP4/Vitamin A in Children with Cleft Lip and/or Palate.Journal of Dental Research, 201493 (6): 547-552.

10. Hong YY, Yu FY, Qu JF, Chen F*, Li TJ*.Fibroblasts Regulate Variable aggressiveness of syndromic Keratocystic and non-syndromicodontogenic tumors.Journal of Dental Research, 201493 (9): 904-910.