Investigators

Research Profiles: 

Research interests are: Bifidobacterium Adolescentis as a delivery system for gene therapy of oral cancers, digital technique application in the management of head and neck surgery, development of robot systems for cranial-maxillofacial surgery, development of megnesium membrane for GBR and GBR.

Research Expertise

Research Theme: 

1. The skull base tumors located in the infratemporal fossa or parapharyngeal space are close to or even invade the brain tissue and internal carotid artery, causing surgical management difficult. We use the digital-aided surgical technology to perform preoperative planning, navigation-guided needle biopsy and tumor resection, improving treatment effectiveness of skull base tumors. At the same time, we have independently developed a needle biopsy and radioactive seed implantation robot for skull base tumors. The robot may provide accurate and minimal invasive treatment in future. 

2. For diagnosis, treatment and prevention of head and neck squamous cell carcinoma,our research focuses on the biomarkers of head and neck squamous cell carcinoma, mechanisms of its cervical lymphatic metastasis, the role of PET / CT and multimodal imaging in the accurate diagnosis of cervical lymph node metastasis, and the role of probiotics Bifidobacterium in immunotherapy of head and neck squamous cell carcinoma. 

3. Guided bone regeneration technique needs proper membrane to cover the transplanted bone. Currently used membranes have their own weaknesses. We developed a degradable magnesium alloy membrane. Animal study showed a good result. The surface modification and properties modulation of the membrane is being studied.

Academic Publications

１． Zhu JH, Deng J, Liu XJ, Wang J, Guo YX, Guo CB. Prospects of Robot-Assisted Mandibular Reconstruction with Fibula Flap: Comparison with a Computer-Assisted Navigation System and Freehand Technique. J Reconstr Microsurg. 2016 Nov，32(9):661-669. IF:1.734

２． Liu LX, Feng ZE, Wang DC, Zhang JY, Guo CB. Prognostic factors in mandibular gingival squamous cell carcinoma: A 10-year retrospective study. Int J Oral Maxillofac Surg 2017: 46:137-143.

３． Zhu JH, Wang J, Wang YG, Li M, Guo YX, Liu XJ, Guo CB. Performance of Robotic Assistance for Skull Base Biopsy: A Phantom Study. J Neurol Surg B 2017;78:385–392.

４． Wang L, Vuletic I, Deng DM, Crielaard W, Xie ZH, Zhou KD, Zhang JM, Sun HF, Ren Q, Guo C1 B. Bifidobacterium breve as a delivery vector of IL-24 gene therapy for head and neck squamous cell carcinoma in vivo. Gene Ther. 2017 Nov; 24(11):699-705. 2017 Aug 14.

５． Xu XL, Luo DM, Guo CB, Rong QG. A custom-made temporomandibular joint prosthesis for fabrication by selective laser melting: Finite element analysis. Med Eng Phys. 2017 Aug; 46:1-11. 2017 Jun 17.

6． Dong F, Taochuan SB, Guo CB, Lv PJ. Detection of cervical lymph node metastasis from oral cavity cancer using a non-radiating, noninvasive digital infrared thermal imaging system. SCIENTIFIC REPORTS. 2018 Jul 10;8(1):10624.

７． Yuan Y, Wang L, Li QX, Guo CB. Retrospective study of survival in human papillomavirus-negative oropharyngeal squamous cell carcinoma treated with primary surgery and associated prognostic factors. ONCOTARGETS AND THERAPY.  2018; 11: 2355–2362.

８． Han ZW, Li QX, Wang YF, Wang L, Li XX, Ge N, Wang YX, Guo CB. Niclosamide Induces Cell Cycle Arrest in G1 Phase in Head and Neck Squamous Cell Carcinoma Through Let-7d/CDC34 Axis. Front Pharmacol. 2019; 9:1544

９． Wang L, Wang YF, Li QX, Tian KY, Xu L, Liu GR, Guo CB. Exopolysaccharide, Isolated From a Novel Strain Bifidobacterium breve lw01 Possess an Anticancer Effect on Head and Neck Cancer – Genetic and Biochemical Evidences. Front Microbiol. 2019; 10: 1044.

１０． Wang TJ, Wang L, Yang HF, Lu H, Zhang JY, Li N, Guo CB. Development and validation of nomogram for prediction of malignant transformation in oral leukoplakia: A large‐scale cohort study. J Oral Pathol Med. 2019 Jul;48(6):491-498.

１１． Lixuan Niu, Dong Zheng, Diancan Wang, Jianyun Zhang, Jun Fei, Chuanbin Guo. Accuracy of F-FDG PET/CT in Detection of Neck Metastases of Oral Squamous Cell Carcinoma in Patients Without Large Palpable Lymph Nodes. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Jan 2020, doi: 10.1016/j.oooo.2019.09.005

１２． Chen XC, Ding JF, XU DH, Cai ZG, Li XE, Shi ZD, Guo CB, Zhou YS. Preventive and control  measures for the coronavirus pandemic in clinical dentistry. Chin J Dent Res, 2020; 23(2):99-104; doi:10.3290/j.cjdr.a44745

１３． Li, Q. X., R. Yang, Y. F. Wang, H. F. Sun, H. B. Wang, H. Liu, Y. X. Guo and C. B. Guo (2020). "MR imaging as a precise technique to evaluate skull-base tumor volume: Comparison of CT, MR imaging and FDG PET from murine and clinical data." J Craniomaxillofac Surg, 2020, 48(1): 105-110.

１４． Niu, L., D. Zheng, D. Wang, J. Zhang, J. Fei and C. Guo (2020). "Accuracy of (18) F-FDG PET/CT in Detection of Neck Metastases of Oral Squamous Cell Carcinoma in Patients Without Large Palpable Lymph Nodes." Oral Surg Oral Med Oral Pathol Oral Radiol, 2020, 129(4): 418-426.

１５． Wang, D. D., H. Y. Luo, C. B. Guo and J. H. Meng (2020). "Clinical and immunohistochemical analysis of diffuse tenosynovial giant cell tumour of the temporomandibular joint." Int J Oral Maxillofac Surg, 2020, 49(7): 882-888.

１６． Wang, Y., Q. Li, L. Niu, L. Xu, Y. Guo, L. Wang and C. Guo (2020). "Suppression of G6PD induces the expression and bisecting GlcNAc-branched N-glycosylation of E-Cadherin to block epithelial-mesenchymal transition and lymphatic metastasis." Br J Cancer, 2020, 123(8): 1315-1325.

１７． Yan, Z. Y., Y. Tan, X. Y. Xie, W. He, C. B. Guo and N. H. Cui (2020). "Computer-aided three-dimensional assessment of periodontal healing distal to the mandibular second molar after coronectomy of the mandibular third molar: a prospective study." BMC Oral Health, 2020,  20(1): 264.

１８． Zhao, M., G. Liu, Y. Li, X. Yu, S. Yuan, Z. Nie, J. Wang, J. Han, C. Tan and C. Guo (2020). "Degradation Behavior, Transport Mechanism and Osteogenic Activity of Mg–Zn–RE Alloy Membranes in Critical-Sized Rat Calvarial Defects." Coatings (Basel) , 2020, 10(5): 496.

１９． Wang, J., Guo, C. B., Zhu, J. H., Guo, Y. X., Yu, G. Y., He, Y., Zhang, W. B., Zhang, Y., Peng, X., Liu, X. J., Liu, Y. P., Gu, X. M., Tian, W. D., Lu, L., Li, Z. B., Zhang, S. L., Shen, G. F., Bao, S., Li, T. J., Fu, K. Y., … Chinese Stomatological Association (2020). Expert Consensus on Procedures and Operations of Navigation-guided Needle Biopsy Techniques for Skull Base Tumours. The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA),, 2020, 23(1), 27–32. https://doi.org/10.3290/j.cjdr.a44333

２０． Han zhenyuan, Ren huiping, Sun jingjing，Wang qin, Guo chuanbin, Tian zhen. Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma. J Transl Med. 2022 Jan 5;20(1):15.  doi: 10.1186/s12967-021-03204-7. IF8.440

２１． Qiao Q, Guo CB, Guo YX. Bone morphogenetic protein receptor 1α promotes osteolytic lesion of oral squamous cell carcinoma by SHH-dependent osteoclastogenesis. Cancer Sci. 2022 May;113(5):1639-1651.  doi: 10.1111/cas.15330.  Epub 2022 Mar 23. IF6.518

２２． Zhu JH，Yan ZY， GuoＣＢ，Ｈａｎ　ＪＭ，Ｃｕｉ　ＮＨ. Feasibility and Efficacy of a Degradable Magnesium-Alloy GBR Membrane for Bone Augmentation in a Distal Bone-Defect Model in Beagle Dogs. Bioinorg Chem Appl. 2022 Mar 23;2022:4941635.  doi: 10.1155/2022/4941635.  eCollection 2022. IF4.724

２３． Ｌｉｕ　ＧＱ， Ｈａｎ　ＪＭ，Ｔａｎ　ＣＷ，ＧｕｏCB. Influences of Extrusion and Silver Content on the Degradation of Mg-Ag Alloys In Vitro and In Vivo. Bioinorg Chem Appl. 2022 Apr 23;2022:2557518.  doi: 10.1155/2022/2557518.  eCollection 2022. IF4.724

２４． Li F，Xu XL， GuoＣＢ，Ｚｈａｎｇ　ＷＧ. Three-dimensional radiological anatomy of condyle trabecular  bone based on a Volume-of-Interest analysis. Dentomaxillofac Radiol. 2022 Sep 1;51(6):20220138. doi: 10.1259/dmfr.20220138. Epub 2022 Jul 12. IF3.525

２５． Ｈｕａｎｇ　ＨＹ， Ｇｕｏ　ＣＢ，Ｇｕｏ　ＹＸ. The Therapeutic Effectiveness Using Fluorescence-Guided Surgery for MRONJ. Biomed Res Int. 2022 Sep 17;2022:1650790. doi: 10.1155/2022/1650790. eCollection 2022. IF3.246

２６． Jianqiao Guo , Junpeng Chen, Jing Wang , Gexue Ren , Qiang Tian , Chuanbin Guo. EMG-assisted forward dynamics simulation of subject-specific mandible musculoskeletal system. J Biomech. 2022 Jun;139:111143.  doi: 10.1016/j.jbiomech.2022.111143.  Epub 2022 May 20. IF2.789

２７． Chao Huang, Xiangliang Xu , Linlin Li, Yuchun Sun, Chuanbin Guo. Study on the reconstruction of a four-dimensional movement model and the envelope surface of the condyle in normal adults. Br J Oral Maxillofac Surg. 2022 Sep;60(7):884-889.  doi: 10.1016/j.bjoms.2021.08.006. Epub 2021 Sep 2. IF2.018

２８． Ke Nan Chen, Jing Wang, Jun Peng Chen, Jun Lin Wang, Yu Chun Sun, Xiang Liang Xu, Chuan Bin Guo. Comparative Study of Temporomandibular Articular Fossa Bone Surface and the Envelope Surface of the Condyle Movement. Chin J Dent Res. 2022 Sep 14;25(3):179-187. doi: 10.3290/j.cjdr.b3317993.

２９． Li QX, Li YK, Qiao Q, Zhao N, Yang YN, Wang L, Wang YF，Guo CB, Guo YX. Oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interlukin-10. Int J Oral Sci, 2023(15):718-728.