Investigators

Research Profiles: 

1. Oral malignant lesion

2. Stem cells derived from oral mucosa

3. Exosomes derived from oral mucosa mesenchymalstem cells

4. Photodynamic therapy

Research Expertise

Area of Research Expertise:

1. Clinical study of oral premalignant lesion

2. Photodynamic therapy for oral premalignant lesion and oral cancer

3. Relationship between oral mucosal mesenchymal stem cell and exosomes in oral premalignant lesions

Research Theme:

1. Mesenchymal stem cells derived from oral mucosa inhibit the proliferation of oral cancer cells

2. Clinical evaluation of photodynamic therapy with oral leukoplakia

3. Oral mucosal mesenchymal stem cell‑derived exosomes as potential therapeutic target in oral premalignant lesions

Academic Publications

1. Zhang Z1, Han Y, Song J, Luo R, Jin X, Mu D, Su S, Ji X, Ren YF, Liu H. Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity. J Oral Pathol Med. 2015 Jan; 44 (1): 15-27. doi: 10.1111/jop.12224. Epub 2014 Sep 12. 

2. Liu H, Liu XW, Dong G, Zhou J, Liu Y, Gao Y, Liu XY, Gu L, Sun Z, Deng D. P16 Methylation as an Early Predictor for Cancer Development From Oral Epithelial Dysplasia: A Double-blind Multicentre Prospective Study. EBioMedicine. 2015 Mar 23; 2 (5): 432-7. doi: 10.1016/j.ebiom.2015.03.015. eCollection 2015 May.

3. Zhang Z1, Song J2, Han Y2, Mu D2, Su S2, Ji X2, Liu H2. Impairment of mesenchymal stem cells derived from oral leukoplakia. Int J ClinExpPathol. 2015 Sep 1; 8(9): 10026-37. eCollection 2015.

4. Song J1, Zhang Z, Ji X, Su S, Liu X, Xu S, Han Y, Mu D, Liu H. Lack of evidence of hepatitis in patients with oral lichen planus in China: A case control study. Med Oral Patol Oral Cir Bucal. 2016 Mar 1; 21 (2): e161-8. 

5. Ji X1, Zhang Z2, Han Y1, Song J3, Xu X4, Jin J1, Su S1, Mu D1, Liu X1, Xu S1, Cui H1, Zhao Z1, Wang Y5, Liu H1.Mesenchymal stem cells derived from normal gingival tissue inhibit the proliferation of oral cancer cells in vitro and in vivo. Int J Oncol. 2016 Nov; 49 (5): 2011-2022. doi: 10.3892/ijo.2016.3715. Epub 2016 Sep 28. 

6. Liu H, Liu Z, Liu XW, Xu S, Wang L, Liu Y, Zhou J, Gu L, Gao Y, Liu XY, Shi H, Sun Z, Deng D. A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study. BMC Cancer. 2018 Sep 24; 18 (1): 918. doi: 10.1186/s12885-018-4787-6. 

7. Zhao Z1, Han Y1, Zhang Z2, Li W1, Ji X1, Liu X1, Jin J3, Xu S1, Cui H1, Cheng Z1, Wang Q1, Wang X1, Guo X1, Wang Y4, Liu H5. Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus. Biomed Pharmacother. 2018 Sep; 105:151-158. doi: 10.1016/j.biopha. 2018.05.076.  Epub 2018 May 29. 

8. Wang X, Han Y, Jin J, Cheng Z, Wang Q, Guo X, Li W, Liu H. Plum-blossom needle assisted photodynamic therapy for the treatment of oral potentially malignant disorder in the elderly. PhotodiagnosisPhotodynTher. 2019 Mar; 25: 296-299. doi: 10.1016/j.pdpdt.2019.01.011. Epub 2019 Jan 8.

9. Han Y, Xu S, Jin J, Wang X, Liu X, Hua H, Wang X, Liu H. Primary Clinical Evaluation of Photodynamic Therapy With Oral Leukoplakia in Chinese Patients. Front Physiol. 2019 Jan 22;9:1911. doi: 10.3389/fphys. 2018.01911. eCollection 2018. 

10. Li W, Han Y, Zhao Z, Ji X, Wang X, Jin J, Wang Q, Guo X, Cheng Z, Lu M, Wang G, Wang Y, Liu H. Oral mucosal mesenchymal stem cell‑derived exosomes: A potential therapeutic target in oral premalignant lesions. Int J Oncol. 2019 May; 54 (5): 1567-1578. doi: 10.3892/ijo.2019.4756. Epub 2019 Mar 19.

11. Wang X, Bai Y, Han Y, Meng J, Liu H. Downregulation of GBAS regulates oral squamous cell carcinoma proliferation and apoptosis via the p53 signaling pathway. Onco Targets Ther. 2019 May 17; 12: 3729-3742. doi: 10.2147/OTT.S207930. eCollection 2019. 

12. Wang X, Jin J, Li W, Wang Q, Han Y, Liu H. Differential in vitro sensitivity of oral precancerous and squamous cell carcinoma cell lines to 5-aminolevulinic acid-mediated photodynamic therapy. PhotodiagnosisPhotodynTher. 2019 Aug 31.pii: S1572-1000(19)30201-7. doi: 10.1016/j.pdpdt.2019.08.036. [Epub ahead of print].