Investigators

Research Profiles: 

1. Oral and maxillofacial surgery

2. Pediatric fibrous tumors 

3. Interstitial brachytherapy of head and neck

4. Multi-disciplinary treatment of pediatric sarcoma of oral and maxillofacial region

5. Basic science of adenoid cystic carcinoma

Research Expertise

Area of Research Expertise: 

Oral and maxillofacial surgery, interstitial brachytherapy of oral and maxillofacial region

Research Theme: 

Oral and maxillofacial surgery, pediatric fibrous tumors, interstitial brachytherapy of head and neck, multi-disciplinary treatment of pediatric sarcoma of oral and maxillofacial region, basic science of adenoid cystic carcinoma

Academic Publications

1. Mao MH, Zhang JG, Zhang J, Zheng L, Liu SM, Huang MW, Shi Y. Postoperative [¹²⁵I] seed brachytherapy in the treatment of acinic cell carcinoma of the parotid gland: with associated risk factors. Strahlenther Onkol. 2014 Oct; 190(11): 1008-14.

2. Jiang Y, Ge XY, Liu SM, Zheng L, Huang MW, Shi Y, Fu J, Zhang JG, Li SL. Nimotuzumab suppresses epithelial-mesenchymal transition and enhances apoptosis in low-dose UV-C treated salivary adenoid cystic carcinoma cell lines in vitro. Anticancer Drugs. 2014 Oct; 25(9): 1052-60.

3. Mao MH, Zhang JG, Zheng L, Gao H, Zhang J, Liu SM, Huang MW, Shi Y. The incidence of radioepidermitis and the dose-response relationship in parotid gland cancer patients treated with 125I seed brachytherapy: incidence of radioepidermitis and the dose-response relationship. Strahlenther Onkol. 2015 Jan; 191(1): 26-33.

4. Fan Y, Zheng L, Mao MH, Huang MW, Liu SM, Zhang J, Li SL, Zheng L, Zhang JG. Survival analysis of oral squamous cell carcinoma in a subgroup of young patients. Asian Pac J Cancer Prev. 2014; 15(20): 8887-91.

5. Zhang J, Zheng L, Liu SM, Huang MW, Shi Y, Wang W, Zhang JG. Brachytherapy for recurrent malignant tumours of the parotid gland. Br J Oral Maxillofac Surg. 2015 Jan; 53(1): 58-62. doi: 10.1016/j.bjoms. 2014.09.016. Epub 2014 Oct 19. PubMed PMID: 25445387.

6. Jiang Y, Feng X, Zheng L, Li SL, Ge XY, Zhang JG. Thioredoxin 1 mediates TGF-β-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma. Oncotarget. 2015 Sep 22;6(28): 25506-19.

7. Fan Y, Huang MW, Zheng L, Zhao YJ, Zhang JG. Three-dimensional verification of 125I seed stability after permanent implantation in the parotid gland and periparotid region. Radiat Oncol. 2015 Nov 24; 10: 242.

8. Liu SM, Wang HB, Sun Y, Shi Y, Zhang J, Huang MW, Zheng L, Lv XM, Zheng BM,Reilly KH, Yan XY, Ji P, Wu YF, Zhang JG. The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary gland malignancies: study protocol of a randomised controlled trial. BMC Cancer. 2016 Mar 7; 16: 193.

9. Huang MW, Zhang JG, Zheng L, Liu SM, Yu GY. Accuracy evaluation of a 3D-printed individual template for needle guidance in head and neck brachytherapy. J Radiat Res. 2016 Nov; 57(6): 662-667.

10. Zheng L, Lv X, Shi Y, Zhang Y, Yu G, Zhang JG. (125) I interstitial brachytherapy for the treatment of myoepithelial carcinoma of the oral and maxillofacial region. Brachytherapy. 2016 Mar-Apr; 15(2): 240-5.

11. Mao MH, Zheng L, Wang XM, Li H, Qin LZ, Zhang J, Han ZX, Zhang JG. Surgery combined with postoperative (125) I seed brachytherapy for the treatment of mucoepidermoid carcinoma of the parotid gland in pediatric patients. Pediatr Blood Cancer. 2017 Jan; 64(1): 57-63.

12. Wu WJ, Guo HQ, Yu GY, Zhang JG. Iodine-125 Interstitial Brachytherapy for Pediatric Desmoid-Type Fibromatosis of the Head and Neck: A Case Report. J Oral Maxillofac Surg. 2017 Apr; 75(4): 768.e1-768.e11.

13. Wu WJ, Shao X, Huang MW, Lv XM, Zhang XN, Zhang JG. Postoperative iodine-125 interstitial brachytherapy for the early stages of minor salivary gland carcinomas of the lip and buccal mucosa with positive or close margins. Head Neck. 2017 Mar; 39(3): 572-577.

14. Huang MW, Wu WJ, Lv XM, Yu GY, Zhang JG. The role of (125)I interstitial brachytherapy for inoperable parotid gland carcinoma. Brachytherapy. 2017 Nov 1. pii: S1538-4721(17)30475-0. doi: 10.1016/j.brachy.2017.09.017. [Epub ahead of print] PubMed PMID: 29102739.

15. Fan Y, Huang MW, Zhao YJ, Gao H, Zhang JG. Radioactive seed migration following parotid gland interstitial brachytherapy. Brachytherapy. 2017 Nov - Dec; 16(6): 1219-1224. doi: 10.1016/j.brachy. 2017.08.007. Epub 2017 Sep 15. PubMed PMID: 28927732.

16. Mao MH, Feng Z, Li H, Qin LZ, Li JH, Huang X, Xing RD, Zhang J, Zhang JG, Han ZX. Comparing the RTOG/EORTC and LENT-SOMA scoring systems for the evaluation of late skin toxicity after (125) I seed brachytherapy for parotid gland cancer. Brachytherapy. 2017 Jul - Aug; 16(4): 877-883. doi: 10.1016/j.brachy.2017.02.011. Epub 2017 May 8. PubMed PMID:  28495444.

17. Wu WJ, Huang MW, Zhang GH, Zhang JG. Mandibular growth in survivors of pediatric parotid gland carcinoma treated with interstitial brachytherapy. Pediatr Blood Cancer. 2018; 65(9): e27223. doi: 10.1002/pbc.27223.

18. Xu N, Zheng L, Wu WJ, Huang MW, Zhang J, Zhang JG. Definitive 125I Brachytherapy of Locally Advanced Adenoid Cystic Carcinoma Involving the Skull Base With Satisfying Efficacy and Safety. J Oral Maxillofac Surg. 2019; 77(10): 2143–2153. doi:10.1016/j. joms.2019.03.031.

19. Zhang GH, Lv XM, Wu WJ, Zhang JG. Evaluation of the accuracy of computer-assisted techniques in the interstitial brachytherapy of the deep regions of the head and neck. Brachytherapy. 2019; 18(2): 217–223. doi: 10.1016/j. brachy. 2018.12. 003.

20. Wu WJ, Li ZY, Dong S, Zhang JG. Texture analysis of pretreatment 18F FDG PET/CT for the prognostic prediction of locally advanced salivary gland carcinoma treated with interstitial brachytherapy. EJNMMI Res. 2019; 9(1): 89. Published 2019 Sep 11. doi: 10.1186/s13550-019-0555-0.