韩冰，教授、主任医师，博士研究生导师。毕业于北京大学，获口腔七年制本硕及口腔正畸学专业博士学位，入选国家“万人计划”科技创新领军人才、科技部中青年科技创新推进计划领军人才，担任Tweed中国中心执行主任、中华口腔医学会正畸专委会委常委，中国老年保健协会口腔医学专委会副主任委员、中国未来研究会未来 生物医学工程分会常委、中国医药教育协会口腔医学分会常委及中华口腔正畸学杂志编委等。

　　研究方向：致力于颅颌面生长发育、错颌畸形数字化诊疗与先进矫治器研发、口腔颌面部组织工程与生物材料的研发与转化等，是梯度性能智选膜片隐形矫治器、传动直丝弓矫治技术和生理性支抗矫治技术团队的主要完成人和推广人。

　　研究成果：主持国家自然科学基金5项、国家重大科学研究计划课题4项、北京市自然重点项目以及首都临床重点转化专项等科研项目20多项，以通讯作者在Nature Biomedical Engineering 、Nature Communications（3篇）、Journal of Dental Research（封面）、Advanced Materials（4篇）、Advanced Functional Materials（5篇）、Bioactive Materials（高被引/年度论文，2篇）、Advanced Science（3篇）、Prog. Orthod.（2篇）、Am. J. Orthod. Dentofac. Orthop.、Angle Orthod.、Orthod. Craniofac. Res.（3篇）等口腔医学、正畸学和生物材料与交叉前沿权威期刊发表SCI论文80多篇，主（参）编中英文教材和专著15部，授权国内外各类专利和软件著作权42项，执笔中国正畸疗效评价标准等专家共识，作为主要完成人获得口腔医疗产品注册证7项，口腔无铅便携式喷雾器获日内瓦展会金奖，先进矫治技术获北京市科技进步二等奖、中华口腔医学科技二等奖、北京医学科技二等奖、中华医学科技奖、北京大学杰出青年医师奖和腾云青年科学家等多项奖励。

　　代表性论文：

　　1.Nan Li, Hao Qin, Fei Zhu, Hao Ding, Yang Chen, Yixuan Lin, Ronghui Deng, Tianyu Ma, Yuanyuan Lv, Changhao Xiong, Rong Li, Yaohua Wei, Jian Shi, Hanqing Chen, Yuliang Zhao, Guangbiao Zhou, Hua Guo, Mengyao Lv, Yongfang Lin, Bing Han*, Guangjun Nie* &Ruifang Zhao*. Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells. Nature Biomedical Engineering，2024，https://doi.org/10.1038/s41551-024-01309-0

　　2.Tingting Yu#, Rushui Bai#, Zeming Wang#, Yuting Qin#, Jingwei Wang, Yaohua Wei, Ruifang Zhao*, Guangjun Nie*, Bing Han*. Colon-targeted Engineered Postbiotics Nanoparticles Alleviating Osteoporosis through Gut-Bone Axis.  Nature Communications, 2024：15:10893

　　3.Bo Wu, Huijing Zheng, Yan-Qi Wu, Zhicheng Huang, Hao-Cheng Thong, Hong Tao, Jian Ma, Chunlin Zhao*, Ze Xu, Yi-Xuan Liu, Zhipeng Xing, Naixin Liang, Fang-Zhou Yao*, Chao-Feng Wu, Ke Wang &Bing Han*. Origin of ultrahigh-performance barium titanate-basedpiezoelectrics: Stannum induced intrinsic and extrinsic contributions, Nature Communications. 2024. 15：7700

　　4.Bo Wu, Lin Zhao, Jiaqing Feng, Yiting Zhang, Xilong Song, Jian Ma , Hong Tao, Ze Xu，Yi-Xuan Liu, Shidong Wang*, Jingtong Lu, Fangyuan Zhu , Bing Han* and Ke Wang *. Contribution of irreversible non-180o domain to performance for multiphase coexisted potassium sodium niobate ceramics. Nature Communications. 2024. 15：2408

　　5.Hao Liu, Yuning Zhang, Yunfan Zhang, Yiping Huang, Yuhui Yang, Yi Zhao, Si Chen*, Jie Deng*, Weiran Li*, Bing Han*.PDLC-apoptosis activates Lepr+ osteoprogenitors in orthodontics. Journal of Dental Research（封面）, 2024，103（9）：937-947.

　　6.Yunfan Zhang, Xueyu Dou, Lingyun Zhang, Hufei Wang, Ting Zhang, Rushui Bai, Qiannan Sun, Xing Wang*, Tingting Yu*, Decheng Wu, Bing Han*, Xuliang Deng. Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration.Bioactive Materials（高被引/年度最佳论文）.2022，11：130-139.

　　7.Yunfan Zhang#，Jiale Yan#，Yuning Zhang，Hao Liu，Bing Han*，Weiran Li，Age-related alveolar bone maladaptation in adult orthodontics: finding new ways out，International Journal of Oral Science，2024，16（1）：51

　　8.Huanhuan Chen, Guangying Song,*, Yi Fan, Jiuhui Jiang, Ruoping Jiang, Xiaoyun Zhang, Gui Chen, Hong Su, Tianyi Wang, Bing Han,*, and Tianmin Xu. Evaluating anchorage and torque control in Class II division 1 adolescent patients among three appliances，American Journal of Orthodontics and Dentofacial Orthopedics ,2025，167：166-176

　　9.Di Zhao, Lei Guo, Qianrui Li, Chunmei Yue, Bing Han,* Kai Liu,* and Huanrong Li*：Multi-functional Lanthanide Metallopolymer: Self-healing and Photo-stimuli-responsive Dual-emitting Luminescence for Diverse Applications， Advanced Materials. 2024, 36: 2405164.

　　10.Yangyong Sun#, Zengzhen Chen#, Huiping Gong, Xueqiao Li, Zhenfei Gao, Shichen Xu, Xiaodong Han, Bing Han,*Xianwei Meng,* and Jin Zhang*. Continuous “Snowing” Thermotherapeutic Graphene. Advanced Materials. 2020,32：2002024

　　11.Yi-Xuan Liu#,, Wanbo Qu#,, Hao-Cheng Thong#,, Yang Zhang, Yunfan Zhang, Fang-Zhou Yao, Trong Nghia Nguyen, Jia-Wang Li, Mao-Hua Zhang, Jing-Feng Li*, Bing Han*, Wen Gong, Haijun Wu, Chaofeng Wu, Ben Xu, Ke Wang*. Isolated-Oxygen-Vacancy Hardening in Lead-Free Piezoelectrics. Advanced Materials. 2022, 34(29): 2202558.

　　12.Jie Deng#, Yu-Ning Zhang#, Ru-Shui Bai, Ting-Ting Yu, Yi Zhao, Hao Liu, Yun-Fan Zhang, Tian-Min Xu*, Bing Han*. Mechanosensor YAP mediates bone remodeling via NF-κB p65 induced osteoclastogenesis during orthodontic tooth movement. Progress in Orthodontics,2025,26: 2

　　13.Qiannan Sun,Zimeng Zhuang, Rushui Bai, Jie Deng, Tianyi Xin, Yunfan Zhang, Qian Li*, Bing Han*. Lysine 68 Methylation-dependent SOX9 Stability Control Modulates Chondrogenic Differentiation in Dental Pulp Stem Cells. Advanced Science,2023,10: 2206757

　　14.Tingting Yu#; Lingyun Zhang#; Xueyu Dou#; Rushui Bai; Hufei Wang; Jie Deng; Yunfan Zhang;Qiannan Sun; Qian Li; Xing Wang*; Bing Han* ; Mechanically Robust Hydrogels Facilitating Bone Regeneration through Epigenetic Modulation, Advanced Science, 2022, 9： 2203734

　　15.Tingting Yu#, Jingwei Wang#, Yusai Zhou, Chao Ma, Rushui Bai, Cancan Huang, Shidong Wang*, Kai Liu*, and Bing Han*, Engineered extracellular vesicles from mesenchymal stem cells as a therapeutic strategy for bone-related diseases. Advanced Functional Materials，2024, 34: 2402861

　　16.Mao-Hua Zhang#,，Qinghua Zhang#,，Ting-Ting Yu#,， Geng Li, Hao-Cheng Thong, Li-Ying Peng, Lisha Liu, Jing Ma, Yang Shen, Zhijian Shen, John Daniels, Lin Gu, Bing Han,*Long-Qing Chen, Jing-Feng Li, Fei Li,* and Ke Wang,*. Enhanced electric-field-induced strains in (K,Na)NbO3 piezoelectrics from heterogeneous structures. Materials Today， 2021，46：44-53

　　17.Yi-Xuan Liu, Jinling Zhou, Yuqi Jiang, Chen-Bo-Wen Li, Chao Li, Jing-Tong Lu, Ze Xu,Fang-Zhou Yao,* Hu Nan, Dawei Wang, Liqiang Xu, Yicheng Wang, Yijia Du, JingkaiNie,Zhixiang Zhu,* Wen Gong,* Bing Han,* and Ke Wang：Multi-Length Engineering of (K,Na)NbO3 Films for Lead-Free Piezoelectric Acoustic Sensors with High Sensitivity，Advanced Functional Materials，2023, 33:2312699

　　18.Kelu Zhao, Bo Li, Yao Sun, Bo Jia, Jing Chen, Wenhao Cheng, Lai Zhao, Jingjing Li, Fan Wang, Juanjuan Su, Jing Sun, Bing Han*, Yawei Liu*, Hongjie Zhang, Kai Liu*. Engineered bicomponent adhesives with instantaneous and superior adhesion performance for wound sealing and healing applications.Advanced Functional Materials. 2023, 33:2303509.

　　19.Zhao Li#, Hao-Cheng Thong#, Yun-Fan Zhang#, Ze Xu, Zhen Zhou, Yi-Xuan Liu, Yue-Yu-Shan Cheng, Shi-Hong Wang, Chun-Lin Zhao, Feng Chen, Ke Bi*, Bing Han* and Ke Wang*. Defect Engineering in Lead Zirconate Titanate Ferroelectric Ceramic for Enhanced Electromechanical Transducer Efficiency. Advanced Functional Materials. 2020, 31: 2005012 .

　　20.Hanlin Huang, Cong Wang, Qi Li*, Ruiqi Wang, Yuying Yang, AidaerMuhetaer, Fuqiang Huang, Bing Han* and Dongsheng Xu*. Efficient and Full-spectrum Photothermal Dehydrogenation of Ammonia Borane for Low-Temperature Release of Hydrogen. Advanced Functional Materials. 2021, 31:2007591.

　　21.Lingyun Zhang#, Yunfan Zhang#, Tingting Yu#, Liying Peng, Qiannan Sun, Bing Han*. Engineered fabrication of enamel-mimetic materials. Engineering. 2022. 14：113-123

　　22.Chunyu Liu#, Yajuan Xie#, Yunfan Zhang#, Yuqi Sun, Yuanbo Wang*, Bing Han*, Xin Jiang*, Bo Wang，MOF-Based Guided Bone Regeneration Membrane for Promoting Osteogenesis by Regulating Bone Microenvironment through Cascade Effects，Advanced Healthcare Materials，2024, 34: 2402861

　　23.Rui Su, Chao Ma*, Bing Han*, Hongjie Zhang, Kai Liu* .Proteins for Hyperelastic Materials, Small ,2025: 2406388

　　24.Chuan Chen, Yan Wang, Zong-Yue Li, Chun Liu, Wen Gong*, Qing Tan*, Bing Han*, Fang-Zhou Yao*, Ke Wang .Evolution of electromechanical properties in Fe-doped (Pb,Sr)(Zr,Ti)O3 piezoceramics，Journal of Advanced Ceramics, 2021，10（3）：587-595 .

　　25.Gao Xin, Zheng Mupeng,* Hou Boyue, Wu Junshu, Zhu Mankang, Zhang Yunfan, Wang Ke, Han Bing.* Recent progress in the auxiliary phase enhanced flexible piezocomposites. Energy & Environmental Materials.2024. e12837

　　26.Tianyi Xin, Qian Li, Rushui Bai, Ting Zhang, Yanheng Zhou, Yuehua Zhang, Bing Han* and Ruili Yang*. A novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/beta-catenin signaling pathway. Stem CellsResearch & Therapy. 2021，12：595-606

　　27.Liying Peng#, Li Chang#, Mengting Si, Jiuxiang Lin, Yan Wei, * Shutao Wang, Hongliang Liu, * Bing Han *and Lei Jiang. Hydrogel-coated Dental Device with Adhesion-inhibiting and Colony-suppressing Properties. ACS Applied Materials & Interfaces. 2020. 12： 9718-9725

　　28.Jie Deng; Zi-Meng Zhuang; Xiao Xu; Bing Han*; Guang-Ying Song*; Tian-Min Xu*. Mechanical Force Increases Tooth Movement and Promotes Remodeling of Alveolar Bone Defects Augmented with Bovine Bone Minera，Progress in Orthodontics. 2024，25：2

　　29.Wenhsuan Lu#，Guangying Song# ,Qiannan Sun , Liying Peng ,Yunfan Zhang , Bing Han*，Jiuxiang Lin. Analysis of Facial Features and Prediction of Lip Position in Skeletal Class Ⅲ Malocclusion Adult Patients Undergoing Surgical-Orthodontic Treatment. Clinical Oral Investigations 2021.25：5227-5238.

　　30.Hao Liu; Yuning Zhang; Wenhsuan Lu; Yuhui Yang; Xiaomo Liu; Si Chen; Weiran Li; Bing Han*，Lower incisor position in skeletal Class III malocclusion patients: a comparative study of orthodontic camouflage and orthognathic surgery,  Angle Orthodontist，2024，94（5）：504

　　31.Qiannan Sun, Rushui Bai, Si Chen*, Zimeng Zhuang, Jie Deng, Tianyi Xin, Yunfan Zhang, Qian Li*, Bing Han*. Lysine demethylase 3A promotes chondrogenic differentiation of aged human dental pulp stem cells, Journal of Dental Sciences.2024，19：86-91.

　　32.JianqiaoYuan#,ZimengZhuang#, LonglongNiu, YuelanZhang,ShuxiaCui, HongSu, GuiChen,XinZhang, Bing Han*,SiChen*.A comparative study on anterior teeth retraction related hard and soft tissue change with physiologic anchorage control technique，European Journal of Medical Research：2024

　　33.Yao Tang, Wenhsuan Lu, Weiqiang Wu, Qiannan Sun, YunfanZhang,Tianmin Xu, Si Chen*, Wei Liang* and Bing Han*. Alveolar bone morphology in patients with palatally-displaced maxillary lateral incisors before and after orthodontic treatment: a cone-beam computed tomography study. Orthodontics & Craniofacial Research，2023

　　34.Huanhuan Chen#, Guangying Song#, Weiran Li, Ruoping Jiang, Xiaoyun Zhang, Si Chen, Gui Chen, Siqi Liu, Fanfan Dai, Fei Teng, Bing Han*, Tianmin Xu*. Subjective and objective analysis of orthodontic expert consensus on the assessment of orthodontic treatment outcomes. Orthodontics & Craniofacial Research，2022

　　35.Fanfan Dai, Si Chen, Tingting Feng, Wenhsuan Lu, Gui Chen, Jiuhui Jiang, Ruoping Jiang, Jiuxiang Lin, Bing Han*, Tianmin Xu*.Accuracy of integration of dental cast and cephalograms compared with cone-beam computed tomography: a comparative study.Odontology, 2022,10.1007/s10266-022-00732-6

　　36.Yiran Jiang#, Guangying Song#, Xiaonan Yu, Yuanbo Dou, Qingfeng Li, Siqi Liu, Bing Han*, Tianmin Xu*. application and accuracy of matching on automated cephalometric superimposition（Featured Article）. BMC Medical Imaging. 2020,20

　　37.Yao Tang, Wenhsuan Lu, Yunfan Zhang, Weiqiang Wu, Qiannan Sun, Yuning Zhang, Xiaomo Liu, Wei Liang*, Si Chen* and Bing Han*.Variations in the alveolar bone morphology in maxillary molar area: a retrospective CBCT study, BMC Oral Health,2024（1）：872

　　38.Hong Su#, Wenhsuan Lu#, Jingjing Deng，Gui Chen，Ruoping Jiang, Xiaoyun Zhang, TianminXu*, Bing Han*. Development of digital diagnostic templates by cluster analysis based on 2249 lateral cephalograms of Chinese Han Population, Head & Face Medicine，2022，18：5.

　　39.Qiannan Sun, Wenhsuan Lu, Yunfan Zhang, Liying Peng, Si Chen* and Bing Han*. Changes of the Anterior Alveolar Bone due to Retraction of Anterior Teeth: A Retrospective Study. Head & Face Medicine，2021，17:30

　　40.Lin-hui Shen, Tian-yi Xie, Ruo-ping Jiang, Yi-ran Jiang, Gui Chen, Tian-min Xu* and Bing Han*. Measurement of three‐dimensional changes in lip vermilion in adult female patients after orthodontic extraction: a retrospective longitudinal study. Head & Face Medicine， 2021，17：9